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Third, the APP/PS1 transgenic mouse model of Alzheimers disease used in Sun 2021 to test Dihexa in an amyloid-pathology model, with Morris water maze, neuroinflammatory cytokines, and PI3K/AKT pathway activation as primary readouts

Thus, results of intervention trials of B vitamin supplementation are conflicting

doi: 10.3390/cells12131700

Kojima M, Kangawa K

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