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[PMC free article: PMC2504781] [PubMed: 18669668] 182

Animals were housed under a 12-h light/dark cycle at 2123C and provided access to food and water ad libitum

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30 This finding shows that PR may be an effective regimen in humans and that it may delay aging by influencing the insulin/IGF-1 signaling pathway, an evolutionarily conserved mechanism that regulates longevity