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In vivo, these structural features translated into strong anti-inflammatory efficacy, where R3 significantly reduced carrageenan induced paw edema and suppressed PGE and leukotriene mediated inflammation, confirming its dual enzyme inhibition

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Following BTZ treatment, transcript levels of macrophage chemokines CC chemokine ligand 3 and C-X-C motif chemokine ligand 2 were elevated in SCs, while CC chemokine ligand 2(CCL2) protein expression was also increased in DRG neurons (Shin et al., 2010

Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG , Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J

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