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MSC- Igf1r / mice were defined as mice that expressed the Nestin-Cre allele and homozygous for the Igf1r floxed allele, whereas the wild type (wt) mice were littermates that were either negative for the Nestin-cre or Igf1r floxed allele

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On the contrary, excessive ROS levels cause cell injury by damaging proteins, lipids, and nucleic acids, leading to different conditions, such as neurological diseases, hypertension, diabetes, atherosclerosis, heart failure, chronic kidney disease, and cancerogenesis [2]