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S-adenosylmethionine levels regulate the schwann cell DNA methylome
Deficiency can lead to the faulty or insufficient production of lipids, from which myelin is composed (25, 26)
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This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]
