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Kidney-selective prodrugs of 6-mercaptopurine: biochemical basis of the kidney selectivity of S -(6-purinyl)-L-cysteine and metabolism of new analogs in rats

2003 Mar;34(2):95-102

Kanasaki K, Kumagai A

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In Figure3, we show model computations of the rates of the glucoronidation reaction, the sulfation reaction and the cytochrome P450 reaction in the liver at 0.5 hours after the dose for a range of doses