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Reciprocally, environmental chemicals can interfere with the composition (Figure 1c) and/or metabolic activity (Figure 1d) of the GI microbiota, with potentially deleterious consequences for the host

This leads to enhanced production of NO, a potent vasodilator that improves endothelial function and vascular tone

Garcia-Ruiz et al., 1994

However, when the cell detects an apoptotic stimulus, such as DNA damage or metabolic stress, the intrinsic apoptotic pathway is triggered and mitochondrial cytochrome c is released into the cytosol ( c and then its translocation through permeabilized OMM

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Thakore P., Clark J.E., Aubdool A.A., Thapa D., Starr A., Fraser P.A., Farrell-Dillon K., Fernandes E.S., McFadzean I., Brain S.D

All efforts were made to minimize animal suffering and reduce the number of animals used
