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The medication cocktail comprises coenzyme Q10, riboflavin, thiamine, idebenone, and dichloroacetate [4]
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Mechanistically, this synergistic effect hinges upon the coordinated targeting of both ER stress and mitochondrial apoptotic pathways
Whilst the focus in primary care may be to screen for dyslipidaemia, for example, to estimate ASCVD in primary prevention or to assess initial treatment response, in a specialist lipid clinic assessment for suspected genetic dyslipidaemia, severe dyslipidaemias and medication intolerance may be more common
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