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A skin biopsy, measurement of metabolites (such as serum methyl malonic acid and homocysteine), and a Schilling test would have thrown more light on the diagnosis

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A similar trial also showed faster angiogenesis with a week of injections in lab animals

Freezing can cause microscopic cracks in the glass vial, potentially compromising the seal

Collectively, these investigations suggested the plausibility of modulating the rate of drug release as well as specifically targeting different GSTs by modifying the sulfonamide moiety 128