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27 (8), e15297

doi: 10.1016/j.cimid.2021.101611 157 ShahbaziRYasavoli-SharahiHAlsadiNIsmailNMatarC

Any compound that potentiates this pathway carries a theoretical risk of promoting neoplastic processes (PMID: 34179015) No Chronic Toxicity Data: Long-term effects of sustained HGF/c-Met potentiation are unstudied even in animal models Uncharacterized Dose-Response: The relationship between Dihexa dose and adverse effects in any living system is poorly defined beyond acute preclinical studies No Regulatory Review: Dihexa has never undergone the systematic safety evaluation required for regulatory submission Safety Comparison Summary: Cerebrolysin has a known, well-characterized safety profile from decades of clinical use

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Its suppression through LAN exposure is hypothesized to facilitate estrogen-dependent carcinogenesis 21

Under normal nutrient circumstances, active mTORC1 phosphorylates and sequesters Ulk1 in a complex with Atg13 and FIP200, thereby inhibiting autophagy