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In all studies that showed a beneficial effect on cognitive functions, the participants were trained or highly trained athletes [13, 17, 19]

Similarly, TBDD faces several challenges, including concerns regarding the long-term use of direct-acting antiviral drugs, which may lead to the emergence of drug-resistant variants in patients

* Correspondence: Bence Raposa, [email protected] Aagndz, [email protected] ORCID: Kezban ahin-Demirci, orcid.org/0000-0001-9278-9130

Although a single mechanism responsible for ARHL is yet to be identified, and is rather unlikely with the multifactorial and cumulative nature of the damage, it is certain that ongoing research efforts to advance our understanding of SNHL, for example with transgenic animal models, high-throughput genome sequencing and proteomics, will further support evidence-based treatment

Derivatization has been applied to catecholamines, sulfur-containing metabolites and proteins, NTs with primary/secondary amines or phenolic hydroxyls, , cholesterol, and corticosteroids to improve ionization and sensitivity

Statistical analysis We initially determined the distribution of data using the Wilks-Shapiro test and then based on the distribution of data the appropriate test was used