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When ER stress is excessive or prolonged beyond the adaptive threshold, UPR signaling can shift from cytoprotective to pro-apoptotic outcomes, frequently through crosstalk with mitochondrial death pathways

Brambilla 2009). 4 Risk Factors Smoking Although there are a variety of causes and risk factors for lung cancer, none are more clearly defined than smoking, which is implicated in approximately 85% of all lung cancers (Larsen 2011)

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doi: 10.1186/s12964-023-01108-1 22 LevineBKroemerG

Methylation processes that regulate epigenesis and imprinting determine the characteristics of the regulatory processes that differ between male and female genomes