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The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers

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To have better therapeutic efficacy, the mechanism of RA pathogenesis, however, need to be further elucidated, especially the interaction among genetic background, environmental factors and immune system, so that effective drugs or therapeutic strategies can be developed to restore the tipped immune balance in RA

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