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Melanoma cells adapt to high levels of ROS by increasing the activity of antioxidant systems such as SOD, CAT, and GPx, which promotes their survival, development of treatment resistance, and ability to form metastases [110]

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[DOI] [PubMed] [Google Scholar] Cossette C

M.JaenischR.LykoF.et al (2016)

[12] [13] BPC-157 has been widely used both by athletes and among the general public, mainly for recovery from injury or stimulating healing in chronic conditions, [14] [11] [15] [16] but there is as yet only very limited human trial data on efficacy and only a few preliminary safety studies

As opposite, in the extracellular medium, a detectable decrease in the concentrations of these proteins would be less likely due to the absence of the cellular machinery for protein degradation