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The results of this test, which was conducted as an accelerated stability test for a product intended for use in refrigerator, were assumed as a 6 month real time data for long term study at room temperature

This results in systemic signaling effects that extend beyond adipose tissue, making these compounds more suitable for studying integrated endocrine regulation rather than isolated metabolic pathways

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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)