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Loss of HIF-1 activity was associated with features of a metabolic switch involving defective anaerobic glycolytic capacity and excessive oxidative phosphorylation together with mitochondrial stress, particularly in monocytes/cDC compartment (figure S3E and S3F)

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reported that a boy with PGK-1 deficiency and his mother, a carrier of heterozygous PGK-1 mutation, both exhibited early-onset PD syndrome

Anbualakan et al

Other antioxidants, such as vitamin C, can regenerate the -tocopheroxy radical to -tocopherol ( Figure 2 ) (reviewed in 1)

Longitudinal TME evolution reveals phase-specific immune landscapes, with minimal residual disease (MRD) and progressive disease (PD) phases exhibiting distinct immunological profiles [57]
