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However, more trials are needed to better understand the effects and mechanisms by which IF modulates the immune system

10.1016/j.expneurol.2017.07.010 210 WojtasA

In some foals affected by this neonatal syndrome, there is minimal ischemic necrosis but instead a profuse distribution of small perivascular and petechial hemorrhages in the cerebrum, cerebellum, and brainstem

doi: 10.1016/bs.pmbts.2022.10.002 60

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Furthermore, preclinical data in breast cancer suggest that inhibition of IGF-1R upregulates INSR-A, leading to IGF-2-induced amplification of Wnt and Notch signaling, which results in the expansion of stem/progenitor populations