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[DOI] [PubMed] [Google Scholar] 6.Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ G

The key distinction: an NNMT inhibitor raises NAD+ indirectly, by protecting its raw material, rather than supplying it directly the way an NMN or NR supplement does

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By blocking the primary drain on cellular NAD+, researchers can observe enhanced mitochondrial function and improved resistance to metabolic stress

Based on these results, we monitored changes in intracellular 1-MNA in response to 24 h treatment with varied 5-amino-1MQ concentrations