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Pyroglutamic acid (also called 5-oxoproline) is a by-product in the gamma-glutamyl cycle

Large doses of nicotinic acid have been observed to impair glucose tolerance, likely because of a decrease in insulin sensitivity

C., Price, J

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At the same time, a previous paper has explained that the interaction between KEAP1 and NRF2 proteins can also be disrupted, affecting the stability of NRF2 and thereby promoting the further progression of breast cancer [117]