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In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups

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Carnosine, through the amino and carboxyl groups in its molecular structure, can compete with sugars to bind the free amino group of proteins, blocking the initial step of the glycosylation reaction, thereby reducing the production of AGEs (8,51)

Reference lists of relevant articles were reviewed as well

This generated a 329 bp and a 104 bp fragment for the homozygous wild type (Ile/Ile) genotype, and a 222 bp, a 107 bp, and a 104 bp fragment for the homozygous variant (Val/Val), with the last two fragments appeared as a single band due to the small size difference (Fig