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In the human genome, complex 7q11.23 region contains NCF1, which codes for the p47phox/Ncf1 protein of the (NADPH) oxidase (NOX2) complex, a necessary component for the induction of ROS ( 2.4 Dual role of ROS in SLE Chronic inflammation in SLE can result in an overabundance of ROS, triggering oxidative stress and leading to DNA damage with localized endothelial and epithelial cell necrosis

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Mammalian target of rapamycin (mTOR) serves as a primary negative regulator of autophagy, directly influencing the ULK1-ATG13-FIP200 complex in response to nutrient availability (17)

However, certain groups, such as older adults and vegans, may require supplements to meet their needs
ROS and TGF- are also produced by HSCs in response to exogenous ROS and TGF- in an autocrine manner