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After being internalized by tumor cells, CuMOF@Pt () disintegrated in a moderately acidic environment and released Cu 2+ and Pt ()

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However, SRT1720 activates SIRT1 expression and reverses the increased A disintegrin and metalloproteinase (ADAM) 17 and the decreased tissue inhibitor of metalloproteinase 3 (TIMP3, an inhibitor of ADAM 17) to reverse the imbalance of renal TIMP3/ADAM17 induced by HG, therefore upregulating the ACE2 expression in HG-treated NRK-52E cells, promoting the translation of Ang II to Ang (17), and playing a renoprotective role in DKD (Guo Z

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