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Highly purified water (typically water for injection, which has undergone multiple distillation or reverse osmosis) is mixed with a precisely measured amount of benzyl alcohol so that the resulting concentration is exactly 0.9% (weight/volume)

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93 Furthermore, PEA exhibits sensitivity to serine proteases, commonly found in inflammatory environments, making it suitable for DDS in OA treatment

The best approach depends on the underlying cause of the deficiency