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Pregnant or nursing individuals should avoid glutathione supplements due to insufficient clinical evidence supporting their safety during pregnancy and breastfeeding

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Pflugers Arch 442:28696 Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y, Makino N, Sugiyama F, Yagami K, Moriguchi T, Takahashi S, Bannai S (2005) Redox imbalance in cystine/glutamate transporter-deficient mice

The cofactors FAD and FMN, which include vitamin B2, are transferred to an electron by the enzyme methionine synthase reductase (MTRR) during the subsequent reactivation cycle

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