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Proposed criteria for efficacious therapeutics in PMS include penetration across the bloodbrain barrier, antagonism of compartmentalized lymphocytes and microglia/macrophages, and amelioration of oxidative stress

doi: 10.1053/gast.2003.50089 20 MediciVHalstedCH

L.PolzellaM.LenziP.FratiA.et al

In addition, a selective GIP agonist showed very low effectiveness in reducing weight, while this co-agonist showed synergism in reducing fat mass in obese rodents

This intricate cascade is known as the classical cGAS-STING signaling pathway (Fig
