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In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue

This aspect of the innate immune response is also known, from a different perspective, as the inflammatory response

Thereby, with some limitations[3], since in the rat it is almost impossible to dissect the hepatic veins[3], few rats studies used occluding the inferior vena cava cranially to the hepatic veins[2,4-7], but bypassing of the occlusion in the rat BCS along with pharmacotherapy treatment was not considered

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Sources: Seiwerth S;Rucman R;Turkovic B;Sever M;Klicek R;Radic B;Drmic D;Stupnisek M;Misic M;Vuletic LB;Pavlov KH;Barisic I;Kokot A;Japjec M;Blagaic AB;Tvrdeic A;Rokotov DS;Vrcic H;Staresinic M;Sebecic B;Sikiric P