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TRANSLATION OF INHALED EXPOSURE THROUGHOUT DRUG DEVELOPMENT: A CASESTUDY ON HOW TO DERISK FORMULATION DEVELOPMENT AND SECURE CLINICAL EXPOSURE Rebecca Fransson 1, Carolyn Stevensson2 & Ulrika Tehler1 1Advanced Drug Delivery, Pharmaceutical Science, R&D, AstraZeneca, 43183 Gothenburg, Sweden 2Early Product Development & Manufacturing, Pharmaceutical Science, R&D, AstraZeneca, 43183 Gothenburg, Sweden Summary: Biopharmaceutics is a skill area residing within pharmaceutical sciences and relates the physicochemical properties of a drug in a dosage form to the pharmacology, toxicology, or clinical response observed after its administration

10.1089/ars.2011.3999 31 GarciaD.ShawR

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2013;1 doi: 10.1002/prp2.1

However, many researchers pointed out that, in practice, the symptom onset is usually impossible to ascertain, and the signs of severity often appear late