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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

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Cancer Res 81: 634647, 2021

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These are as follows Pharmacogenetic studies in ADHD should be methodologically rigorous in terms of the pharmacological intervention, which means that the trial should meet criteria for being published on its own