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These picomolar levels of 15-HpETE-PE alone (Supplemental Figure 4A, generated under IL-13 plus arachidonic acid conditions) would be insufficient to directly oxidize the nanomolar changes caused by oxidation of GSH to GSSG observed in response to IL-13 (or the change with inhibition of 15LO1 or KD of ALOX15 /15LO1)

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10.1016/j.jot.2024.05.004 J Orthop Translat

Cardioprotective effect of total saponins from three medicinal species of dioscorea against isoprenaline-induced myocardial ischemia