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As with major depression, reviews of trials indicated that omega-3 supplementation may have a positive effect as an adjunct to therapy in patients with bipolar disorder (192, 194)

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nevertheless, data on AD seem controversial since a large study and a Mendelian randomization revealed a causal association between genetically elevated CRP and reduced risk for AD, while another study reported that genetically predicted increased CRP may be a causal risk for AD [578,579,580]