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Extensive functional diversification of the Populus glutathione S-transferase supergene family

First isolated in 1974 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during electrically induced slow-wave sleep, DSIP was the first endogenous peptide identified specifically in the context of sleep regulation

93 Animal studies have indicated that age-related disruption of nave T cell survival and homeostasis depends on alterations in the secondary lymphoid environment and IL-7 (a maintenance factor) signaling

Galectin-3 is expressed in several cells, particularly activated macrophages and has been reported to be involved in fibrotic diseases in the liver, kidney, lung, and so on [106]

GHK protected lungs from lipopolysaccharide-induced damage by suppressing infiltration of inflammatory cells into lungs and reducing inflammatory response

Hyperglycemic stimulation of PKC- in atrial cardiomyocytes activates the NF-B/TGF- signaling pathway, leading to increased expression of pro-inflammatory and pro-fibrotic mediators such as TNF-, TGF-, and signaling molecules like p-IB, p38 MAPK, Cav1.2, and NCX