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Interestingly, oral vitamin B 12 replacement therapy was also effective for the patients with a history of gastrectomy

10.1016/j.cmet.2016.05.006 [DOI] [PMC free article] [PubMed] [Google Scholar] 6.Schultz MB, Sinclair DA

For weight loss patients whose exercise capacity is limited by fatigue, correcting B12 deficiency often produces a meaningful improvement in what they're able to do
Malabsorption Issues: This is often the more complex reason

Researchers combining these compounds should start with conservative doses of each and monitor closely for unexpected effects
