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Its main benefits include: Simple storage Long duration Easy self-administration Trimix was developed in 1983 when scientists discovered that adding phentolamine and alprostadil to papaverine, at the time a standalone ED treatment, created an improved compound.[4] Today, Trimix injections are an accepted second-line ED medication when oral PDE5 inhibitors, like Viagra, Levitra or Cialis, are ineffective or create side effects.[3] Since Trimix works locally where it is injected, rather than circulating throughout the bloodstream like oral drugs, it tends to have a lower risk of side effects

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This contrasted with the spared gross liver presentation, counteracted hepatomegaly and splenomegaly, reduced gross lesions in the stomach, duodenum and intestine, lower serum enzyme values, and no congestion of the central vein or branches of the terminal portal venules in BPC 157-treated rats
