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Cell Metabolism , 31(3), 529544

Allergic reactions: Rarely, ingredients such as methionine or preservatives may cause an allergic reaction including itching, rash, or breathing difficulty

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Semaglutide was initiated at 0.25 mg per week for the first 4 weeks via a pre-filled pen injector, escalating in a fixed-dose regimen every 4 weeks to reach the maintenance dose of 2.4 mg by week 16 (lower maintenance doses were permitted if participants were unable to tolerate 2.4 mg) (Extended Data Fig