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423 Methotrexate was approved for the treatment of psoriasis more than 50 years ago by the US Food and Drug Administration (FDA)

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Batarseh A., Papadopoulos V

3 Intestinal permeability Semi-permeability or selective permeability is a crucial feature of the intestinal wall

10.3390/agronomy9120860 78 GruiescuR

Unlike the results found in previous studies, the effect of high dose N -acetylcysteine on air trapping and airway resistance of chronic obstructive pulmonary disease, a double-blinded, randomized, placebo-controlled trial (HIACE) conducted with 120 patients with stable COPD (58 treated with 600 mg of oral NAC twice a day and 62 with placebo), demonstrated a significant improvement in the function of the small airways, in addition to a reduction in the frequency of exacerbation of the disease [53]