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doi: 10.3390/ijms252111563

118,119,120,121 In addition, it has been observed that naive T cells from older individuals exhibit reduced responsiveness to the superantigen toxic shock syndrome toxin-1 compared to younger individuals, 122,123 which may be caused by low dual specificity phosphatase 6 levels in naive T cells, resulting in a rise in the threshold of TCR activation

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These findings are particularly relevant in metabolic syndrome and gout, where elevated uric acid levels are common and contribute to vascular dysfunction through redox imbalance

PMID: 9407550, PMCID: PMC2230240, DOI: 10.1007/bf03401712

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