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Garzya G, et al

"There is evidence to support caffeine's benefits for both physical and mental performance, but the timing of consuming caffeine, the form of caffeine, your current caffeine use, and the amount consumed must be carefully considered

I had one patient who developed serious problems while watching a basketball game

Because CAR interacts with DR-1 elements in different promoters 46 , and the first 299 bp of the human SHBG promoter contains a perfect consensus DR-1 sequence at 70 bp from the start site of transcription 8 , we performed luciferase reporter gene assays in HepG2 cells using wild-type or mutated DR-1 SHBG proximal promoter constructs co-transfected with either hCAR or mCAR, and treating them as previously with or without resveratrol

So we [consumers] are already getting two times the amount of caffeine, and thats not including any other drinks that a young athlete would consume during the day. Celsius poses significant health risks to adolescents due to their high caffeine content and the potential for developing early tolerance

Dakin RS, Walker BR, Seckl JR, Hadoke PWF, Drake AJ
