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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

In epilepsy, upregulated P 2 Y 1 receptor signaling disrupts Ca 2+ dynamics and enhances glutamate release

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Neither form is automatically better for every patient

The UV-visible spectroscopy measured the absorbance [optical density (OD)] of the sample at 595 nm

doi: 10.1631/jzus.B2100266