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4 The regulatory role of gut microbiota dysbiosis in the pathogenesis of IBD Clinical data indicate a significant positive correlation between gut microbiota dysbiosis and the onset and progression of IBD, manifested specifically as reduced -diversity, depletion of commensal probiotic bacteria, and abnormal proliferation of pro-inflammatory pathogens (83)

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Nevertheless, a European guideline recommends that eGFR should be monitored in at least 3-month intervals in children with CKD started on rhGH treatment, and that treatment should be discontinued in patients presenting with an unexplained decline in eGFR [154]

However, repeated measurements of the Lp(a) level are recommended in patients whose Lp(a) concentration in the first measurement was 3050 mg/dl (75125 nmol/l), i.e

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