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Additionally, blocking sialylation with pharmacological agents like ambroxol sensitizes the tumor to immune checkpoint blockade (ICB) therapies, such as anti-PD-1 and anti-CTLA4, significantly improving tumor control and extending survival in preclinical models

Funding This work was supported by the National Natural Science Foundation of China (32130038), the Chinese Ministry of Science and Technology (2024YFA1306501 and 2022YFC2303700), the China Postdoctoral Science Foundation (2021M700242 and 2022T150017), and the Young Elite Scientists Sponsorship Program by CAST (2022QNRC001)

One of the projects that really highlighted HISP Ugandas work was the Saving Mothers and Giving Life (SMGL) project

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Clusters 2, 4, and 5 were identified as profibrotic lipid-associated macrophages (LAMs) because of high expression of profibrotic genes (Fn1, Spp1, CD44) and lipid metabolism genes (Lpl, Trem2, Fabp4, Fabp5)