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However, despite compelling experimental and computational evidence, clinical translation remains limited due to challenges in bioavailability, standardization, and longterm efficacy

According to few recent studies, treatments with hemin can attenuate cytokine storms in animal model of sepsis, indicating the putative role of HO-1 in the protection against the cytokine storm syndrome observed in COVID-19 patients (244)

doi: 10.3390/jcm11092551 6 SolbergDKRefsumHAndreassenOABentsenH

10.3233/JAD-201556 205 SrivastavaA.ShivanandappaT

Plant Cell 22, 31183129