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The cell then converts THF to 5, 10-methylene THF ( Fig

Lon protease binds PYCR1, a key enzyme in proline metabolism, enhancing NADPH consumption and promoting electron leakage in the ETC, thereby elevating mtROS (45)

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Disulfiram modulated ros-mapk and Nfb pathways and targeted breast cancer cells with cancer stem cell-like properties

For individuals with underlying conditions that contribute to B12 deficiency, such as pernicious anemia or gastrointestinal disorders, follow-up care may involve managing these conditions to optimize B12 absorption