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Subsequent work established that the same sequence exists in human plasma, saliva, and urine at concentrations that decline with age, and that the sequence is found as a subfragment of the alpha-2 chain of type I collagen, which means GHK is released into the tissue environment when collagen breaks down

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Small dense LDL is associated with metabolic risk, but much of its risk appears to be mediated by higher ApoB-containing particle number