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Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

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To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green