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Aquated cisplatin avidly binds DNA, with a predilection for nucleophilic N7-sites on purine bases, resulting in 1,2- or 1,3-intrastrand crosslinks (Ming et al., 2017)

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Through interactions with neurons, microglia regulate crucial processes such as neuronal activity, synapse formation and survival, and the remodeling of presynaptic circuit (Badimon et al., 2020