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BSO is an inhibitor of GSH synthase that has been used to deplete GSH in vitro , including in macrophages (11, 12), and is more specific than GSH-depleting agents such as diethylmaleate that can activate nrf2 directly due to its electrophilic properties (13)

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Pour compenser la baisse naturelle du glutathion Avec lge , la production de glutathion diminue , rduisant les dfenses de lorganisme vis--vis du stress oxydatif

10.1016/j.tibs.2013.12.006 Trends Biochem

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