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they are rooted in measurable physiological dysfunctions, including severe oxidative stress, mitochondrial impairment, and systemic inflammation

actual dose females: 0.1, 1, 14, 143, 1430 g/kg bw, respectively 1.6, 16, 199, 1988, 19,880 nmol/kg bw) (Supplementary Table S1)

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For instance, in a study on patients undergoing chemotherapy for breast cancer, actigraphy data revealed significant circadian disruption, with irregular sleepwake patterns