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NAC reduces oxidative levels but may impair antitumor immune responses mediated by ICD in certain contexts [264]

Inflammatory cytokines released by activated microglia and astrocytes (IL-1, TNF-, IL-6) upregulate the iron importer protein, DMT1, and downregulate the iron exporter protein, FPN1, promoting iron accumulation in neurons [179, 180]

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One lead was subsequently optimized in the micro-batch-under-oil format at 23 C using a drop volume ratio approach (Luft et al, 2007)

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