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By suppressing ACC, AOD9604 reduces lipogenesis the formation of new fat deposits
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Their therapeutic effects primarily involve strengthening antioxidant defenses by enhancing GPX4 and GSH activity, reducing ROS accumulation, and limiting iron-induced lipid damage, thereby protecting hepatocytes
Their carcinogenicity primarily arises from redox imbalance leading to oxidative stress, inhibition of DNA repair systems, and direct genotoxic effects through DNA adduct formation and chromosomal damage [208]
Parkinsons disease Parkinsons disease (PD) is a long-term neurodegenerative disorder that affects the motor system, characterized primarily by the death of dopaminergic neurons in the substantia nigra and the presence of intracellular aggregates of misfolded -synucleine (Lewy bodies) in the surviving neurons 54,55
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