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Reduction of NNMT activity in research models may lead to observable changes in nicotinamide metabolism, methyl group utilization, and downstream cell signaling

Common treatments include repeated phlebotomy and the use of iron chelators

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Comment: Commenters expressed various concerns over the use of CAHPS Hospice Survey measures and the CAHPS Hospice Survey Index as an appropriate indicator in the proposed SFP algorithm, while also acknowledging the importance of including caregiver voices in the algorithm

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